Treatment of anal fissure with nitroglycerin

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Breakthrough treatment proves 90 success rate on painful anal fissures. Previous reports have suggested initial efficacy in the treatment of anal fissures. The aim of this study was to assess the longer-term usefulness of this treatment. Methods thirty-three patients with an anal fissure were treated with topical 0. 3 nitroglycerin ointment, applied to the anoderm three times per day and after bowel movements. Topical nitroglycerin (ntg), a nitric oxide donor compound, has been shown to cause relaxation of the anal sphincter and may have treatment efficacy in the management of anal fissure. User reviews for nitroglycerin to treat anal fissure and fistula. The goal of treatment is to relieve pain and discomfort, and heal the torn lining. Acute anal fissures -- the ones that dont last longer than 6 weeks -- are common and usually heal on their own. In 98 of patients the fissure healed with conservative nonsurgical treatment. The combination of nifedipine and botulinum toxin was superior to nitroglycerin and pneumatic dilatation with respect to both healing (94 v. There was no statistical difference between the number of dilatations and botulinum toxin injections needed.).   treatment of benign anal disease with topical nitroglycerin. Author information (1)mount sinai school of medicine, new york, new york, usa. Purpose fissure-in-ano and acutely thrombosed external hemorrhoids are common, benign anal conditions, usually characterized by severe anal pain. These may include a medicated cream (to help heal the fissure), a topical muscle relaxant (to relax the anal muscles), an anesthetic ointment (to reduce pain, if pain interferes with having a bowel movement), or nitroglycerin or calcium channel blocker ointments (to relax the anal muscles and increase blood flow to the region, promoting healing).   medical treatments can therefore be used in individuals wanting to avoid surgical treatment, and surgery can be reserved for treatment failures in adults with chronic typical fissure. Topical application of calcium channel blockers may be as effective as nitroglycerin ointment in the treatment of anal fissure, without the risk of headache, which many patients find unacceptably painful.   anal fissure is a painful condition that is caused by anodermal tearing after the passage of hard stool. Severe cases result in involuntary internal anal sphincter spasm and have traditionally been treated surgically with a lateral sphincterotomy. Investigators have demonstrated that nitric oxide causes relaxation of the smooth muscle of the anal canal, so topical nitroglycerin ointment. Breakthrough treatment proves 90 success rate on painful anal fissures.

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